A cross-sectional study of type -2 diabetic females at a higher cvd risk owing to a strong correlation of systolic hypertension to cvd risk factors

Authors:Dr. Purvi Purohit
Int J Biol Med Res. 2012; 3(3): 1895 - 1899.  |  PDF File

Abstract

Aim - We aimed at evaluating the CVD risk in the female type 2 diabetic patients as compared to the type – 2 diabetic males at diagnosis.Background - India faces dual epidemic of diabetes and CVDs. Hypertension affects approximately 70% of patients with diabetes and is approximately twice as common in persons with diabetes as in those without. The hypertensive diabetic women with coronary heart disease appeared to be under-diagnosed. Materials & Methods – The study included 280 subjects (healthy controls – 50 males & females, 180 DM -2 – 98 females, 82 males). The patients were selected on the basis of symptomatology & a FBS > 126 mg/dl and were analysed for BMI, BP, serum Insulin, HOMA – IR, C – peptide, Lipid profile & apo –B & A1. CVD risk was assessed using T.chol/HDL and apo – B/apo A1 ratios. Statistical analysis was done using the students -‘t’ test and spearman’s coefficient of correlation.Results – The DM -2 patients presented with raised BMI, hypertension, dyslipidaemia, hyperinsulinemia, HOMA - IR & raised serum C – peptide (p<0.0001, HS) as compared to the healthy controls. Hypertension was observed in 39.79% female & 40.24% male diabetics. But the SBP was significantly raised in the diabetic females as compared to the males (p = 0.04). However, DBP had a NS difference (p = 0.47). The female & male diabetics had comparable biochemical parameters. Correlative analysis showed a strong association of SBP in the female type – 2 diabetics with potential CVD risk biochemical markers & CVD risk ratio T.Chol./HDLc but a NS association was observed in male diabetics. Conclusion – The type two diabetic females have a higher CVD risk as compared to males at comparable levels of biochemical parameters, probably due to a greater mean systolic hypertension in them, which in turn is strongly associated to potential CVD risk markers (insulin, HOMA –IR, C –peptide & T.Chol/HDL ratio).