Non alcoholic fatty liver disease in patients with type 2 diabetes mellitus

Authors:ShivanandaPai, Chakrapani M, Deepak R Madi, Basavaprabhu Achappa, Unnikrishnan B
Int J Biol Med Res. 2012; 3(3): 2189-2192  |  PDF File

Abstract

Background and Objective: Nonalcoholic fatty liver disease (NAFLD) has emerged as the most common cause of chronic liver disease worldwide.Type2Diabetes mellitus (DM) is a risk factor for progressive liver disease and mortality in patients with NAFLD, whereas NAFLD is a marker of cardiovascular risk and mortality in patients with type 2diabetes. Hence, the diagnosis and evaluation of fatty liver is an important part of management of diabetes. We conducted a study to determine anthropometric and metabolic parameters in diabetic patients with NAFLD. Anthropometric and metabolic parameters in diabetic patients with fatty liver were compared with diabetic patients without fatty liver. Research Design and Methods: 44 patients with type 2 diabetes mellitus attending diabetic clinic of a tertiary care hospital participated in the study. 30 diabetic patients had fatty liver and 14 diabetic patients without fatty liver acted as controls. History and thorough clinical examination including anthropometry (waist hip ratio and body mass index (BMI) ) and lab investigations were done.Ultrasound abdomen was done to detect fatty liver .Anthropometric and metabolic parameters in diabetic patients with fatty liver was compared with diabetic patients without fatty liver. Results : In our study diabetic patients with fatty liver had a highbody mass index( BMI), high waist hip ratio ,elevated SGPT /SGOT ratio(>1) and deranged lipid profile when compared to diabetic patients without fatty liver.This was found to bestatistically significant. Conclusions: Increased waist hip ratio and BMI would act as early anthropometric indicators in prediction of NAFLD in type 2 diabetic patients. SGPT / SGOT ratio>1could act as biochemical marker for prediction of development of fatty liver in diabetic patients.