Antihyperglycemic and antilipidperoxidative effects of flavanoid naringin in streptozotocin-nicotinamide induced diabetic rats

Authors:Leelavinothan Pari, Selvaraju Suman
Int J Biol Med Res. 2010; 1(4): 206-210  |  PDF File

Abstract

Aims: In light of evidence that some complications of diabetic mellitus may be caused or exacerbated by an oxidative stress, the putative protective effect of naringin was investigated in streptozotocin-nicotinamide induced diabetic rats. Methods: Naringin was given for 42 days at a daily dose equivalent to 80 mg/kg of body weight. Lipid peroxidation levels and non-enzymic antioxidants such as vitamin C, vitamin E and glutathione were than measured in plasma. Results: Under our experimental conditions, naringin was found to significantly reduce the blood glucose and increase the plasma insulin level in diabetic rats. Our results suggest that the antihyperglycemic action of naringin is exerted via the stimulation of insulin secretion. In addition, naringin appears to exert an antioxidative property demonstrated by the increase of vitamin C, vitamin E and glutathione levels in plasma and a lowering of lipid peroxidation levels in plasma. Conclusion: In conclusion, naringin possess a potential hypoglycemic effect in streptozotocin-nicotinamide induced diabetic rats.