A comparative study of haematological parameters in type i diabetes mellitus patients & healthy young adolescents.

Authors:Ruchi Kothari, Pradeep Bokariya
Int J Biol Med Res. 2012; 3(4): 2429-2432  |  PDF File

Abstract

Aims: The present study was undertaken to evaluate and compare the haematological parameters related to the erythrocytes in a cross-section of type 1 diabetic patients with those of the healthy young adolescents of Jodhpur region. Material & Methods: A total of 30 normal young adolescents in the control group and 28 type1 diabetes mellitus patients in experimental group of age 8-15 years were examined for total RBC count, Haemoglobin concentration, Packed cell volume and MCHC (Mean Corpuscular Haemoglobin Concentration). All hematologic variables were fitted into normal distributions, and parametric analysis using mean, Standard deviation (S.D.), Standard Error (S.E.) was done. For validation of observations, Student’s “t” test has been employed. Results: The mean Total RBC count in the control group was found to be 4.77 million per cubic mm whereas it came out to be 3.94 million per cubic mm in the experimental group. The average Hb concentration in control group was 12.86 g/dl and that in diabetic subjects was 11.45 g/dl. The value of PCV in both categories was 41.56 % and 40.07 % respectively. Similarly the MCHC was taken out to be 31.24% for the controls and 28.45 % for the experimental group. Conclusion: The mean values of TRBC, Hb, PCV, MCHC for the diabetic patients were found to be lower than the values of control group, indicating the presence of anemia in the former group. Since anemia has been known to be a risk factor for cardiovascular disease in diabetic patients with chronic kidney disorder, it is therefore an important observation that development of anemia in type 1 diabetes may predate an abnormality in renal function. Furthermore, understanding the mechanism by which this occurs may provide the opportunity to develop therapeutic options that may improve patient outcomes.