High sensitive c reactive protein insulin resistance and coronary artery disease risk

Authors:Sowjanya. B , B.Phanikrishna ,E .Venkat Rao.
Int J Biol Med Res. 2012; 3(4): 2570-2574  |  PDF File

Abstract

Inflammation and insulin resistance (IR) are forerunners of cardiovascular disease (CVD) and diabetes .Asians have an underlying pro inflammatory state that may contribute to their increased risk for CVD and type 2 diabetes.This study was aimed at proving high sensitive C-reactive protein ( hsCRP ) ,IR as risk factors for CVD, hs CRP is also associated with metabolic syndrome. 133 subjects of mean age 48 yrs, both males & females attending cardiology department for master health check up were included in this study. Anthropometric measures (height, weight, body mass index(BMI), waist circumference(WC), blood pressure), biochemical parameters( fasting plasma glucose(FG), serum total cholesterol (TC), triglycerides(TGL), High density lipoprotein cholesterol(HDLc), fasting insulin , hs CRP) were measured in all subjects. Insulin resistance is measured by Homeostasis model for assement of insulin resistance( HOMAIR ).Based on hs CRP two groups were divided-group1 with CRP <3 mg/L, group2 with hs CRP > 3 mg/L . All the parameters were compared between the groups, correlation was also observed. Statistical analysis used: Pearsonís correlation coefficients were used to assess the associations, studentís t test, and multivariate binary logistic regression analysis was used to compare the groups p value is significant for HDLc(p<0.008) fasting glucose (FG)(p=0.035), HOMA IR(p<0.04) .BMI is positively related with hs CRP, the mean hs CRP levels were elevated with increasing number of metabolic syndrome components. Gender specific analysis showed that HDLc, HOMAIR were significant predictors of inflammation in males but not in females. According to this study , variables like HDLc, HOMAIR were significant predictors of inflammation . Inflammation is associated with metabolic syndrome . Hence ,the role of inflammation in CVD can provide new opportunities for diagnosis& treatment.