Seroprevalence of cytomegalovirus in healthy voluntary blood donors in renowned jordanian hospital

Authors:Ababneh Hani
Int J Biol Med Res. 2012; 3(3): 2193-2195  |  PDF File


Abstract- : Cytomegalovirus (CMV) is one important cause of transfusion-associated in morbidity and mortality infecting immuno-suppressed individuals. Aim: The goal of this study was to determine the seroprevalence of antibodies to CMV in blood donors at KHMC Methods: The seroprevalence of CMV antibodies was tested using CMV IgG/IgM Chemiluminescence’s by Immulite 2000 system. and Enzyme linked sorbent immune assay -ELISA Results: Of the 2000voluntary blood donors screened for CMV, 1800 were positive and 200 were negative for IgG antibodies, with CMV positive prevalence rate of 90%. All of the IgG positive blood donors were negative for CMV IgM antibodies. About 96% of the donors aged between 30 to 39 years were seropositive for CMV, as against 91.9% in those aged 20-29 years, 88.6% in 40 to 49 years, 75.0% (3 out of 4) in 50 to 59 years, and 100% (1 out 1) in 60-69 years. There was no statistically significant difference (P>0.05) in the CMV IgG status in different age groups. The highest rate was found in adult male blood donors units (1800 out of 2000), making sex comparisons statistically undesirable. Conclusion: 90% of blood donors at KHMC were CMV IgG seropositive, it is advisable to screen blood donors in Jordan for CMV to identify the CMV-seronegative blood donors, and maintain an inventory of them for use as donors. We conclude that CMV IgG titer in blood units is high with possibly subsequent transmission of infection but a single serum titer is of limited diagnostic value in determining active disease.