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Nt-probnp levels in detecting heart failure in patients with left ventricular systolic dysfunction presenting with diabetes mellitus and hypertension

Authors:Rohini K, Sam Annie Jeyachristy, Srikumar P S,Surekha Bhat, Mahesh Kumar A
Int J Biol Med Res. 2012; 3(3): 2250-2253  |  PDF File


Purpose: Plasma levels of N-terminal pro b-type natriuretic peptide (NT-proBNP) have gained importance as markers in detecting, diagnosing, and evaluating the severity of heart failure.Patients with diabetes and hypertension are at higher risk of heart failure. The aim of the present investigation was to assess whether NT-proBNP can be used to detect early heart failure in patients with left ventricular systolic dysfunction (LVSD) accompanied with diabetes and hypertension.Materials/Methods: Forty patients with coronary artery disease (CAD) were recruited for this study and were grouped as diabetes mellitus (DM, n= 9), hypertension (HTN, n=8), bothDM and HTN (DM+HTN, n=15) and without DM and HTN (None, n= 8). Echocardiography (ECHO) findings, Fractional Shortening (FS) and Ejection Fraction (EF) were assessed to detect LVSD and NT-proBNP levels were also measured in all patient groups before and after coronary artery bypass graft (CABG).Results: ECHO findings were found to be decreased (p<0.001) in patients with DM and HTN before CABG, when compared to CAD patients who neither had DM nor HTN. After CABG, FS and EF was significantly improved in all patient groups.NT-proBNP levels were significantly increased(p<0.001; p<0.01) in all patient groups before CABG and were decreased (p<0.001) after CABG. Correlation analysis showed negative correlation between the echo findings and NT-proBNP levels.Conclusions: From the results, it could be speculated that NT-proBNP levels supports echo findings in detecting early heart failure in LVSD patients with DM and HTN.