The effect of ketamine on blood pressure, heart rate, respiratory rate and intraocular pressure in patients undergoing ocular procedures

Authors:Omar S. Almomani
Int J Biol Med Res. 2012; 3(3): 2163-2164  |  PDF File

Abstract

Aim: to evaluate the effect of ketamine on blood pressure, heart rate, repiratory rat and intraocular pressure on patients undergoing ocular surgeries. Method: a prospective study conducted at Prince Ali Bin Al-Hussein hospital in Al-Karak city in the south of Jordan between July 2011 and July 2012. All patients who were scheduled for ocular surgeries under general anesthesia were included in this study. Patients who are younger than 10 years of age, or those with previous systemic medical diseases or glaucoma or taking long term medications were excluded from the study. All patients included in this study received no medication prior to ketamine injection which is given as intra venous injection using a dose of 3mg/kg. Blood pressure, respiratory rate, pulse rate and intra ocular pressure were measured immediately prior to injection and at 3,6 and 9 minutes after the injection. Results: Only one patient showed change in the heart rate at 6 and 9 minutes after receiving ketamine and this change was increase of about 25%. On the other hand one patient at 3 minutes and 2 patients at 6 and 9 minutes showed increase in blood pressure of about 10-15% and only 2 patients showed increase in respiratory rate at 3,6 and 9 minute of about 10%. Regarding intraocular pressure 4 eyes at 3 minutes and 6 eyes at 6 and 9 minute showed elevation of intra ocular pressure, however this elevation ranged between 2 to 4 mmhg (7-10%) and the intra ocular pressure remained within the normal range after elevation. Conclusion: Ketamine has no significant effect on intra ocular patients with no history of pre-operative elevation in intra ocular pressure and it is recommended to be used as anesthetic agent for diagnostic and short time ocular procedures.