Assessment of contribution of fasting and post meal plasma glucose to increased glycated hemoglobin in diabetes mellitus ----a comparative study

Authors:S.W. Masram, M.V. Bimanpalli
Int J Biol Med Res. 2012; 3(3): 2020-2024  |  PDF File

Abstract

BACKGROUND: Pattern of Glycemic control is found to be different in type-1 & type-2 diabetes mellitus(DM). Hyperglycemia and its correlation with glycated hemoglobin in both types of diabetes mellitus have been well studied and informative to the diagnostic, therapeutic & prognostic aspects of diabetes mellitus. AIM: To interpret & establish the correlation of glycated hemoglobin (GHb or HbA1c ) with both fasting plasma glucose (FPG) and post meal plasma glucose (PMPG) in type-1& type-2 DM. MATERIAL AND METHODS: fifty each already diagnosed patients of type-1 and type-2 diabetes mellitus along with fifty control were studied for glycated hemoglobin and plasma sugar status. STATISTICAL ANALYSIS: we have used student t-test and Pearsonís correlation coefficient to find the statistical significance. RESULT: Fasting as well as post meal plasma glucose and serum percentage of glycated hemoglobin were increases simultaneously in both the types of DM as compared to that of control but hike was seen in the Type-2 Diabetes Mellitus. PMPG is high significantly & positively correlated with glycated hemoglobin (P<0.001) in all the three groups of study. CONCLUSION: Prominent Hyperglycemia & poorer glycemic control are seen in the type-2 DM than those in type-1 DM. Our study revealed that PMPG is appreciably contributes to the glycated hemoglobin rather than FPG in both type-1 & type-2 diabetes mellitus.