Chances and obstacles of pilot projects in animal research for statistical sample size calculation

Abstract

Animal experiments are a core element of basic medical research. Their accurate planning regarding sample size, however, poses a challenge from a biometrical point of view, since valid information is rarely given. One proposed concept includes the integration of pilot projects in animal research to encounter this shortcoming. The undoubtedly resulting advantages of this approach regarding the estimation of the required sample size though have to be discussed critically and should be contrasted to potential obstacles and practical implications, respectively.