Oxidant stress in primary nephrotic syndrome in relation to dyslipidemia

Authors:Angoorbala Bafna, Purnima Dey Sarkar
Int J Biol Med Res. 2010; 1(4): 144-148  |  PDF File

Abstract

ABSTRACT Nephrotic Syndrome is a consequence of an imbalance between oxidants and antioxidants. The present study aimed to assess oxidants and antioxidants status in relation to dyslipidemia in adults Nephrotic Syndrome patients and during remission. The study dealt with 75 adults diagnosed to have primary Nephrotic Syndrome (PNS) and all were given standard oral corticosteroid induction therapy and 50 normal healthy adults were kept for control. Blood samples were analyzed for quantification of albumin, malondialdehyde (MDA) as an index of lipid per-oxidation ,Total cholesterol(TC), Triglycerides(TG), High density lipoprotein cholesterol (HDL-C), Low density lipoprotein Cholesterol(LDL-C),Total antioxidant capacity (TAC), Copper and Zinc from control and experimental patients. Significantly increased level of MDA, TC, and TG was noted while significantly decreased levels of HDL-C TAC, Zinc and Copper were noticed in the patients with Nephrotic Syndrome as compared to healthy control. However, after standard corticosteroids induction therapy significant reduction in MDA, TC, TG, were observed but no significant change in LDL-C was observed. Although improvement in TAC, HDL-C albumin, Zinc and Copper were observed after standard corticosteroids induction therapy.