Evaluation of c reactive protein and tumor necrosis factor alpha as reliable laboratory markers for early diagnosis of sepsis

Authors: Ganesh D Ghuge , Rahul Zine, Mukund Mogrekar
Int J Biol Med Res. 2012; 3(4): 2345-2347  |  PDF File

Abstract

Background: Sepsis and septic shock are common causes of mortality in critically ill patients. The high mortality rate associated with the sepsis underlines the need for reliable laboratory marker for early identification of patients at high risk. Microbiological diagnosis of sepsis is usually difficult and time consuming. The demonstration of increase in the level of certain cytokines can be used as indirect evidence of sepsis. Objective: The present study was conducted with an aim to determine the relevance of C-reactive protein (CRP) and serum tumor necrosis factor α (TNF- α) and C-reactive protein (CRP) as diagnostic markers of sepsis. Materials and methods: One hundred and sixty two patients diagnosed as sepsis clinically were included as study, serum levels of CRP and TNF-α were estimated. Results: Serum CRP levels were found to be elevated in 91 (89.2%) sepsis patients. Serum TNF- α levels were elevated in 98 (96.1%) sepsis patients. Conclusion: Estimation of CRP and TNF- α can be useful for empiric management of sepsis cases.