Cytogenetic analysis of benign prostate hyperplasia [bph] patients

Authors:H.M.Chauhan, H.K.Prajapati, H.H.Modi, S.M.Chaudhary, C.A.Pensi
Int J Biol Med Res. 2012; 3(4): 2342-2344  |  PDF File

Abstract

Background & objectives: Benign prostate hyperplasia [BPH] is the classical age related disease of prostate, present in 20% of men at the age of 40 years with progression to 70 % by the age of 60 years. BPH is associated with various lower urinary tract symptoms, which affect their day to day life. The aim of the present investigation was to find out the major chromosomal aberrations present in BPH patients and to make a comparison with other study. Methods: In present study 20 cases of benign prostate hyperplasia were taken on the basis of clinical diagnosis from the various hospitals located in Ahmedabad, Gujarat, India, during the period of March 2011 to October 2011. The patients were analyzed for chromosomal aberrations using cultured peripheral blood lymphocytes with their pre-informed written consent. Results: In the present study, 15 (75 %) cases were in the age group of > 60 years. In this study, Karyotype analysis reveals ¬¬¬01 (5%) BPH patient had 46, XY, del (16q-). AUASI score is >20 in 16 (80%) patients. Conclusion: BPH is found in > 60 years of age in 75 % of cases. Common chromosomal aberration 46, XY, del (16q-) found in ¬¬¬01 (5%) BPH patient. Severe AUASI score (>20) is found in 80% of cases.