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Rem sleep deprivation – a stressor

Authors:Thamaraiselvi K, Mathangi DC ,Subhashini AS
Int J Biol Med Res. 2012; 3(4): 2390-2394  |  PDF File


As the world is moving forward with a lot of development in materialistic aspects, health is taking a back seat. The basic need in life – ‘sleep’ is the one, that is most affected and sleep deprivation is becoming common. Sleep deprivation has been shown to have deleterious effect on the human body, giving rise to many diseases and disorders and especially REM sleep deprivation is shown to affect the HPA axis. This cause an increase in cortisol secretion, which is related to stress. The aim of this study is to assess the effect of REM sleep deprivation on plasma corticosterone. Wistar strain male albino rats were used to study the effect of REM sleep deprivation. They were divided into three groups, control, REM sleep deprived and REM control. Inverted flower pot technique was used to achieve REM sleep deprivation. Heparinised blood sample was taken and assessed for plasma corticosterone level. Food intake and body weight were also monitored to know the effect of REM sleep deprivation. The values obtained were statistically analysed using one way analysis of variance (ANOVA). On significant f test ratio, Tukey’s multiple comparison tests were also performed. The level of significance was kept at P<0.05. All the results obtained from the study are expressed as mean + standard deviation (SD). The results of this study showed an increase in plasma corticosterone level, 24 hrs (34.725* ± 7.5), 48hrs (43.17* ± 9.2), 72hrs (35.17* ± 5.7) and not much change in 96hrs (10.96 ± 3.62) when compared to the control animals (12.293 ± 3.790). Corticosterone is a hormone related to stress; hence an increase in corticosterone level shows that REM sleep deprivation is a stressor. Sleep is important in life and deprivation of REM sleep can cause stress and affect the quality of life.