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Anti-diabetic effects of alcoholic extract of cosciniumfenestratum through pancreatic cell protection and partial regeneration induction in streptozotocin-induced diabetic rats

Int J Biol Med Res. 2012; 3(4): 2609-2615  |  PDF File


The study aims to evaluate the effects of the stem ethanolic extract of Cosciniumfenestratum on Streptozotocin-induced diabetic rats. Rats were divided into 4 groups. Group 1 and 2 which served as normal and diabetic controls, respectively, did not receive the extract. A prevention group (group 3) was daily orally fed with the extract (250 mg/kg BW) for 2 weeks prior to diabetic induction. A therapeutic group (group 4), received the extract after the onset symptoms of diabetes. Blood glucose and body weight were measured every 3 days within further period of 6 weeks after the extract feeding. Pancreases were collected and histological evaluated. The results revealed the extract has the anti-diabetic effects by protection the severe weight loss due to diabetes, and reduced hyperglycemic. Morphometric analyses of the islets showed no changes of the mean area of the islets and the distances between the adjacent islets, implied atrophy was not obvious. Histological profile showed less damage and more compact arrangement of the islets cells in prevention group compared to the diabetic control group, whereas in therapeutic group also found the partial regeneration of the islets cells. The results suggest the compounds in the extract exert their effects through the protection of cells and stimulation of cell regeneration. The balanced of damaged and regenerated cells should improve insulin production and secretion.