Adenocarcinoma of duodenum is a rare gastrointestinal tumor accounting for 2% of all gastrointestinal malignancies. Diagnosis is most often delayed because of vague and nonspecific symptoms and sign. Hence time lag between initiation of cancerous lesion to clinical presentation, diagnosis and treatment of the disease is associated with consequent poor outcome. In present case report we describe clinical presentation, diagnostic modalities and management of 64 year old male who was diagnosed as adenocarcinoma of duodenum. He underwent Whipple’s pancreaticoduodenectomy. Adjuvant chemotherapy was also administered.