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Pre and post operative immune status in patients enduring cardiac surgery

Authors:Nagarajan Prabhu , Divya T. Raj, Yamunagowri, Danialas Joseph Pushpa Innocent
Int J Biol Med Res. 2010; 1(4): 253-258  |  PDF File


Pre and post operative levels and T and B lymphocytes and immunoglobulin (IgG, IgM and IgA) were studied in 120 patients suffering from chronic rheumatic heart disease (RHD) / non-RHD and undergoing open and closed heart surgery (OHS/CHS). A highly significant rise (p<0.001) in percentage of active T cells is observed in both RHD ad non RHD groups of patients as compared to controls with no significant difference in the proportion of total T cells. B cells showed highly significant rise (p<0.001) only in RHD group. OHS has shown to produce more significant depression in T cell counts than that produced by CHS. No significant change was seen in the percentage of B lymphocytes after OHS as well as CHS. This study revealed highly significant (p<0.001) raised levels of IgG, IgM and IgA in study group as compared to controls. Significant post operative fall in the levels of IgG and IgA was recorded after OHS as well as CHS even though the fall was found to be more significant after open cardiac procedure. Levels of IgM did not show any post operative change in both OHS and CHS groups of patients. A study of post operative infections in these patients revealed Staphylococcus aureus as a major isolate followed by Pseudomonas aeruginosa, Proteus vulgaris. Patients with OHS showed higher post infection rate than in CHS patients.