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Study of iron profile in sickle cell disease patients

Authors:J P WARADE, I C APTE, H S DAHAKE, Y R PAWADE
Int J Biol Med Res. 2013; 4(3): 3271-3274  |  PDF File  |  Category: General Medicine

Abstract

Context: Study of Iron Profile in Sickle cell Disease Patients Objectives: Tofind out the weather sickle cell disease is iron overload or iron deficiency state. Study Design: A cross-sectional analyticalstudy. Materials & Methods: Concentrations of serum iron, total iron binding capacity and ferritin were analyzed and compared between sickle cell 4disease cases and healthy controls by using the unpaired two-tailedStudent’s ‘t’ test. All statistical analyses were done using Graph Pad Prism. Results: The mean levels of serum iron and ferritin levels were significantly (P< 0.05) lower in sickle cell disease cases as compared to healthy subjects. Whereas total iron binding capacity was significantly (P< 0.05) higher in sickle cell disease case as compared with normal healthy subjects. Conclusion: Sickle cell disease is an iron deficiency state as contrary to conventional belief of iron overload state. Thus, in the course of treatment of sickle cell disease the fact that these individuals are in iron deficiency state should be taken into consideration.