Aim: This study was conducted to study the distribution of ABO blood group and Rhesus factor among Malay, Chinese, Indian and other races’ students in Asia Metropolitan University, Malaysia. Method : 428 students were involved in this study. They were divided into 4 different groups named as Malay, Chinese, Indian, Others. 107 students (male and female) were chosen randomly and being placed in each respective group. A 1.0-2.0 ml sample of blood was drawn from the antecubital vein of each subject in a disposable syringe, and transferred immediately to a tube containing ethylene diamine tetra acetic acid (EDTA). Blood grouping (ABO) and Rhesus factors (Rh), was done by the antigen antibody agglutination test. The anti sera used were obtained from Plasmatec Laboratory, Great Britain. Result : Blood group O was prevalent among Malay, Chinese, Otheretnics but among Indians blood group B was prevalent. Blood group AB was least prevalent. Among rhesus positive races, blood group O was prevalent and blood group AB was least prevalent. Among rhesus negative races, blood group B was prevalent and blood group A and AB were sharing the same percentage respectively that was 0.23%. Conclusion: Blood group O was most prevalent and blood group AB was least prevalent. When narrowly focused interestingly Indians were having blood group B as most prevalent but for Malay, Chinese, Others etnics, blood group O were most prevalent. Another interesting finding was almost 67% rhesus negative were among the Indians and only 33% rhesus negative were distributed among Malay and Others etnics with no rhesus negative were recorded for Chinese etnic. From the present finding, Indians are having unique blood group distribution when compared to other etnics live in Malaysia.