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Serum uric acid, homocysteine and lipid peroxidation status in patients of coronary artery disease

Authors:Sunny Chopra, A.K Lal, Meenakshi Dhar
Int J Biol Med Res. 2013; 4(3): 3333-3338  |  PDF File


Coronary artery disease (CAD) is one of the major causes of mortality and morbidity in India. Over the last two decades, it has been seen that along with other risk factors like diabetes, hypertension, smoking, alcohol etc, the free radicals (FR) and reactive oxygen species (ROS) play an important role in the development and progression of atherosclerosis. Oxidative stress enhances the possibility of low density lipoprotein (LDL) oxidation and development of atherosclerotic plaque formation. Hence the present study was planned to assess the levels of various oxidative stress markers like malondialdehye (MDA), uric acid and homocysteine in patients of CAD and explore their role in the causation and progression of coronary artery disease.The other parameters included in the study were cardiac biomarkers like creatine kinase CK-MB, Aspartate transaminase (AST), Troponin-I and lipid profile. The studied population consists of fifty three CAD patients and fifty normal healthy controls. The levels of MDA and homocysteine were extremely raised in the CAD patients than controls (<0.0001). Serum uric acid level was found to be significantly high in patients of CAD when compared with healthy controls. The levels of CK-MB, AST, total cholesterol, triglycerides, low density lipoprotein cholesterol (LDL-C) and very low density lipoprotein cholesterol (VLDL-C) were significantly raised in CAD patients. High density lipoprotein cholesterol (HDL-C) levels were significantly lower in patients of CAD.This study concluded that increased level of MDA could prove the presence of oxidative stress in the patients of CAD. Increased levels of homocysteine, uric acid and lipid profile might contribute to additional risk factors in the development of atherosclerosis.