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A review on the link between vitamin d and diabetes mellitus

Authors:Ram Hanno , Anushi Bulumulle , Bindu BNSS Gandrapu , Atul Jain , Vishal Patel
Int J Biol Med Res. 2013; 4(3): 3523-3526  |  PDF File

Abstract

Serum vitamin D levels of 50 - 125 nmol/L are considered sufficient, 30 - 49 nmol/L as insufficient and below 30 nmol/L as overtly deficient. Large demographics of the general population are affected, the majority being at below optimal blood levels for a variety of reasons. A study published in the Archives of Internal Medicine has estimated Vitamin D deficiency levels in approximately 85% in the general population. The role of vitamin D in diabetes (autoimmune type 1, type 2 diabetes mellitus) is considerable. Deficiency or insufficiency of vitamin D is linked to autoimmune dysfunction potentially playing a significant part in development of type 1 autoimmune diabetes in both children and adults.There is also an observable relationship between vitamin D deficiency and glucose intolerance, insulin resistance and insulin secretion. There is an association between increased development of diabetic neuropathy in vitamin D deficient diabetics. Vitamin D deficiency is an independent risk factor for neuropathy after adjusting for demographicfactors, BMI, comorbidity, use of medications for neuropathy and diabetes duration