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Platelet count, mean platelet volume, serum creatinine and delayed clotting time as surrogate markers of type 2 diabetes mellitus

Authors:S.V.Umadevi,Dr. Jyoti John, Nitin John.
Int J Biol Med Res. 2014; 5(2): 3970-3974  |  PDF File


ABSTRACT; Diabetes Mellitus is a metabolic syndrome characterized by hyperglycemia resulting in complications affecting the nerves, kidneys, eyes and micro- and macrovascular structures. It has been suggested that abnormal platelet functions and endothelial damage may play a role in pathogenesis of microangiopathy in diabetes mellitus. Platelet size is predictor for recurrent myocardial infarction. Abnormalities of mean platelet volume have been observed in diabetic patients. Aims: This study evaluates platelet count and mean platelet volume correlated to fasting blood sugar, postprandial blood sugar, body mass index, serum creatinine and clotting time and duration of diabetes mellitus. This study been carried out prior to the onset of vascular complications and can be used as a diagnostic & prognostic test in the management of diabetes mellitus. Method: About 1000 diabetics were screened and 60 uncomplicated type 2 diabetes mellitus patients were selected & compared to 60 healthy subjects. Blood was drawn for estimation of blood sugar. The platelet count & mean platelet volume was estimated by using cell Dyne 1700 automatic cell analyzer. Result: The mean platelet volume was correlated to fasting blood sugar (r-0.6755 & p<0.0001) and post prandial blood sugar(r-0.5416 & p<0.0001) which is highly significant as compared to controls .There was significant increase in p value for clotting time (p<0.04254 & r 0.1048),serum creatinine(p 0.0333 & r-0.2757). Mean platelet volume showed no significant correlation with body mass index (p 0.0517 & r-0.2525) nor with duration of diabetes (p 0.731 & r-0.979). Platelet count from uncomplicated NIDDM showed no significant rise as compared to normal healthy controls. Conclusion: Mean platelet volume, serum creatinine and delayed clotting time can be taken as surrogate markers of type 2 diabetes mellitus