Study of serum lipid profile in type 2 diabetes mellitus in male and female: more apparent in postmenopausal and premenopausal female

Abstract

There is increasing evidence from epidemiological studies that females were prone at higher level to Type 2 Diabetes Mellitus (T2DM) then T2DM male. Moreover, postmenopausal diabetic female have highest elevated risk of cardiovascular disease. However, it is still uncertain whether the estrogen itself contributes significantly to this increase in risk. Consequent of the cross-sectional analysis of 30 T2DM patients and 20 control, age and sex matched healthy individuals (group),these patients and controls subject were classified as male (15 patients, 10 controls), females (15patients, 10 controls). Females then subdivided into premenopausal females (7 patients, 5 controls) and postmenopausal females (9 patients, 5 controls) were reported. The data revealed significant elevation of serum total cholesterol, triglycerides, LDL-cholesterol, VLDL-cholesterol, except HDL-cholesterol which is decreased significantly, in all diabetic patients when compared with those of control groups. Female patients had higher level, of total cholesterol triglycerides, LDL-cholesterol, VLDL-cholesterol and low HDL-cholesterol, compared to age matched male patients. However, there was no significant difference in the triglycerides between the diabetic premenopausal, and postmenopausal females, and a significant reduction in the level of HDL-cholesterol in the postmenopausal group, and significant increase in the value of the total cholesterol and LDL-cholesterol. The results also conclude that the diabetic postmenopausal females are more prone for hyperlipidemia than diabetic premenopausal females.