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Study of serum malondialdehyde level in pre-eclampsia

Authors:Bhagyashree k Bhuyar, Mohammed Shamsuddin
Int J Biol Med Res. 2014; 5(3): 4159-4162  |  PDF File


ABSTRACT The current theory suggests that in preeclampsia there is an increase in the lipid peroxidation products and leads to a decrease in the plasma antioxidants except uric acid and changes in the lipid profile levels, contributing to the pathogenesis of preeclampsia. In this context, this study was undertaken to determine the changes in plasma levels of lipid peroxide, in women with preeclampsia. Objectives:.To measure the levels of serum malondialdehyde in pre-eclampsia in comparison with normal pregnancy. Materials and Methods: Study consisting of 30 preeclamptic and 30 healthy pregnant women. Fasting venous blood samples were collected during antepartum period and plasma level of malondialdehyde is estimated.Results: In the preeclamptic group malondialdehyde, a lipid peroxidation product was significantly increased. Conclusion:The findings of the present study are consistent with previous studies, suggesting that lipid peroxidation is important factors in the pathogenesis of preeclampsia.