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distribution of candida species in various clinical specimen in a tertiary care centre , kerala, india. .

Authors:Regha I R, Prithi Nair. K, Anoop Sinha
Int J Biol Med Res. 2014; 5(2): 4093-4097  |  PDF File


There is an emerging trend for non-albicans Candida (NAC) species in causing infections. A descriptive study was done to determine the isolation rates of Candida albicans and NAC species. A total of 95 consecutive pure cultures of Candida from various clinical specimens submitted to Microbiology lab from different units of a tertiary care centre, Kerala from August 2010 to July 2011 was studied using conventional yeast identification methods. The percentage of isolation of NAC species was 67% and that of C.albicans was 33%. The predominant species isolated was C. tropicalis (45%) , followed by C. albicans (33% ) and C. parapsilosis ( 22%). As it is possible to predict the sensitivity pattern of each Candida species with high accuracy, it is necessary to identify the Candida isolates up to the species level. This will help to optimize the therapeutic decisions regarding rational antifungal therapy. All the three species obtained in this study are not intrinsically resistant to fluconazole: thus, this drug can be used for empirical therapy in cases where uncomplicated candidiasis is suspected. However , indiscriminate use of fluconazole should be tempered by good clinico-microbiological correlation, in order to prevent the emergence of azole resistant species as a result of undue selection pressure.