Lipoprotein (a) in sudanese diabetic patients correlated with glycosylated heamoglobin

Abstract

Background: Diabetes mellitus (DM) is the most common endocrine-metabolic disorder in children and adolescents. It is characterized by high incidence of cardiovascular disease (CVD). The cause of increased risk of CVD in diabetes is multi-factorial, important factors include dyslipidaemia and poor glycaemic control. Problem: The Sudanese diabetic patients may have high frequency of dyslipidaemia, which may contribute significantly to accelerated coronary atherosclerosis. Aim: This study aim is correlation of lipid profile with glycosylated haemoglobin (HbA1C) in Sudanese diabetic patients. Materials and methods: In this crosssectional study, the lipid profile and HbA1C levels of 219 Sudanese diabetic patients were diagnosed after informed or verbal consent. Enzymatic methods and chromatographic technique were applied to measure lipid profile and HbA1C, respectively. Results and Discussion: All Sudanese diabetic patients participated in this study had a lipoprotein (a) Lp (a) concentrations >30mg/dl, this level exceeded the cut-off value of Lp (a). However, Lp (a) concentration at the level ≥ 100mg/dl represent 33.3% of the total diabetic cases. This indicates a high risk for those patients. Greater than 40% of diabetic patients were having HbA1C level >9.0%, hence they were at increased risk of cardiovascular complications, because they were considered having poor glycaemic control. Lp (a) seen to be a determinant risk factor of all diabetic patients. Diabetic patients under study were at poor glycaemic control. Addition of Lp (a) to the routine lipid profile to assess cardiovascular risk in diabetic patients may enhance management of diabetes mellitus