Correlation of blood glucose with urinary titrable acidity, urinary ammonia and net acid excretion among type 2diabetes mellitus patients in south india.

Abstract

Objective: In this paper, an attempt is made to correlate blood glucose with urine titrable acidity, ammonia and net acid excretion among type 2 diabetes mellitus patients in south india . Materials and methods: one hundred individuals are included in this study, 70 cases (36 males&34 females) and 30 controls (16 males &14 females). Estimation of blood glucose and estimation of serum creatinine were done by commercial kit methods. Urine titratable acidity is done by titrating urine with 0.1m NaOH using phenolphthalein indicator and the same titrated urine is used for estimating ammonia by adding formaldehyde and again titrating with 0.1m NaOH. Results: blood glucose was statistically correlated, significantly with creatinine (r=0.292, p=0.007) and blood glucose was statistically not correlated with urinary titratable acidity, urinary ammonia and net acid excretion. There is statistically significant intercorrelation is seen between Urinary titratable acidity, urinary ammonia and net acid excretion. Comparision between cases and controls showed, there is increase in urinary titrable acidity, urinary ammonia and net acid excretion in cases compared to controls. Conclusion: If blood glucose is increased there is increase in creatinine levels and increased levels of urinary ammonia, urinary titratable acidity and net acid excretion is noticed.