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Effect of mev electron beam irradiation on fracture healing of tibia bone of rabbit

Authors:Suvendu Kumar Sahoo , Biswajit Mallick , Indramani Nath , Rabi Narayan Mukharjee
Int J Biol Med Res. 2014; 5(4): 4569-4577  |  PDF File

Abstract

The study was undertaken by taking six numbers of clinically healthy eight to twelve months old New Zealand white rabbits of either sex, weighing about 1-2 kg body weight. The animals were provided with standard diet and maintained under uniform managemental conditions. A destruction of one tibia bone was done of all rabbits. Then (two male and one female) fracture sites of the three rabbits were irradiated with single fraction 0.5 Gy dose by 4 MeV Electron beam using Linear Accelerator after proper immobilization just after fracture of bone. Other three rabbits (two male and one female) were taken as control samples. X-Rays diffraction and Fourier Transform Infrared Spectroscopy analysis techniques were used for confirmation of particular 0.5 Gy dose for irradiation. The results of radiological image and clinical findings indicated that the fracture healing occurred faster in all rabbits with MeV electron irradiation than in those without irradiation. It is due to more accumulation of bone forming material like both inorganic hydroxyapatite and organic collagen at fracture site after electron beam irradiation.