Cyto-histo grading correlation in breast malignancies

Abstract

Background : A palpable breast lump is a common diagnostic problem. The breast lesions are spectrum of diseases ranging from non- neoplastic to neoplastic lesions. Fine Needle Aspiration Cytology (FNAC) is an important tool in the diagnosis of breast lesions. It is important not only to diagnose breast lesion as benign or malignant, but also to assay the prognosis. Objectives of study : The purpose of the present study was to compare cytologic grading of breast carcinoma by Simplified Black grading system with histologic grading by Nottingham modification of Bloom-Richardson grading system. Methods : The study included smears from 25 cases of palpable breast lump diagnosed as malignant on FNAC. The cytological grading by Simplified Black system was compared with histopathologic grading by Nottingham modification of Bloom Richardson. The statistical test used was Chi – square test. Results : Cytologic grading by Simplified Black system and histologic grading by Nottingham modification of Bloom Richardson done in 25 cases of breast carcinoma had good correlation (p value < 0.05). Conclusion : Fine needle aspiration cytology is a safe, rapid and minimally invasive procedure for the diagnosis of breast lesions. It is effective replacement for open biopsy. Cytologic grading by Simplified Black system correlates well with histologic grading by Nottingham modification of Bloom Richardson. Hence it must be included in the cytology report of breast carcinoma whenever possible as it helps in determining the tumour aggressiveness and further treatment plan.