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Levels of the proinflammatory cytokines: interleukin-8, interleukin-12, tumor necrosis factor-α in severe acne at makassar

Authors:AI Anwar , MN Massi , IJ Patellongi , W Dewiyanti
Int J Biol Med Res. 2015; 6(1): 4718-4721  |  PDF File


Background : The etiology of acne vulgaris (AV) is uncertain, in general, it is a multifactorial disease. Propionibacterium acnes induces toll-like receptor-2 (TLR-2) which causes the release of proinflammatory cytokines such as Interleukin-8 (IL-8), Interleukin-12 (IL -12) and Tumor Necrosing Factor (TNF-α). This mechanism leads to inflammation and tissue damage in AV that will affect the incidence of severe AV. Methods : This study aims to know the levels of IL-8, IL-12, and TNF-α in AV patients with severe lesions using a descriptive study. Results : 83 patients with severe AV obtained varying levels. Levels of IL-8 varied between 25.32 -64,783.43 pg / ml with an average (mean) ± 11035.00 14768.00 pg / ml, IL-12 levels varied between 17.98 to 61.33 pg / ml with a mean of 24.48 ± 6.84 pg / ml, and TNF-α levels varied between 13.18 to 239.84 pg / ml with a mean of 158.73 ± 52.32 pg / ml. Conclusion : The result of descriptive analysis from the three proinflammatory cytokines was that interleukin-8 has the highest levels in AV patients with severe pustules lesions.