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Telmisartan prevents myocardial fibrosis : telmisartan decreases tgf-β1 and collagen fraction volume myocardial tissue in wistar rats induced high salt intake

Authors:Widharto Prawirohardjono, Rachmat Hidayat
Int J Biol Med Res. 2015; 6(3): 5050-5054  |  PDF File

Abstract

The beneficial effects from variation doses of telmisartan prevents myocardial fibrosis in wistar rats induced high salt intake.Ten-week-old male Wistar Rat (n = 30) were used. Wistar Rats were randomized into five groups. Group 1 : 6 rats as negatif control. Group 2 : 6 rats were induced for heart fibrosis by intake Nacl 8% doses 2% body weight for eight weeks. Group 3 : 6 rats were induced for heart fibrosis by intake Nacl 8% doses 2% body weight and telmisartan 3 mg/kgBB for eight weeks. Group 4 : 6 rats were induced for heart fibrosis by intake Nacl 8% doses 2% body weight and telmisartan 6 mg/kgBB for eight weeks. Group 5 : 6 rats were induced for heart fibrosis by intake Nacl 8% doses 2% body weight and telmisartan 12 mg/kgBB for eight weeks. Fraction volume collagen and concentration of TGF-β1 in myocardial tissue were assessed. Fraction volume collagen and TGF- β1 significantly decreased in group 4 (high salt intake and telmisartan 6 mg/kgBB) and 5 (high salt intake and telmisartan 12 mg/kgBB) compared in group 2 (only high salt intake).Telmisartan prevents myocardial fibrosis. Telmisartan decreases TGF-β1 and fraction volume collagen in myocardial tissue wistar rats induced high salt intake.