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Comparison of biochemical and hormonal changes in metformin – clomiphine citrate and metformin – letrozole in pcos south indian women’s

Authors:Ganesan Dhanalakshmi , Palaniswamy Sumathi ,Palanisamy Pasupathi , Muthuswamy Ganadeban
Int J Biol Med Res. 2011; 2(2): 490-496  |  PDF File


To determine whether metformin- clomifene citrate and metformin – letrozole combined drug treatment has beneficial effects on biochemical and hormonal changes in infertile polycystic ovary syndrome (PCOS) Women in an infertility clinic. All patients between the age of 27 and 37 years who attended a infertility clinic with a suspicion of PCOS. PCOS patients in both groups were received 1500 mg metformin (Glucophage, Merck, West Drayton, UK) a day (500 mg three times a day) for 6–8 weeks. If pregnancy occurred, the patient was excluded from the study. However, in case of failure of pregnancy after the end of this period, the patients in the group III were given 100 mg clomiphene citrate and group IV patients received 2.5 mg letrozole (Femara, Novartis, Quebec, Canada) from 3-7 days of their menstrual cycle. The demographic characteristics like body weight, BMI, hirsutism, menstural status was significantly (p<0.001) decreased, Biochemical parameters such as glucose, cholesterol have the significant difference (Fig II) But, lipid profile have not significantly differ after the treatment period. Endocrinological parameters of thyroid hormones were not significantly differ. But, Insulin , LH, FSH and testosterone hormones have a significant difference after the treatment period. In the present study we suggest, Comparatively Metformin – letrozole have a better result in demographic, Biochemical and endocrinoligical parameter. Especially PCOS patient androgen metabolisms were highly alter. Its exceedingly helpful to induce the ovulation and pregnancy level of infertile PCOS patients.