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Seroprevalence of transfusion transmissible infections among blood donors attending in a rural teaching hospital at sangareddy

Authors:Nagababu Pyadala, Soumendra Nath Maity*, Prudhvi Chand Mallepaddi, Neha Sharma G, Ratna Giri Polavarapu
Int J Biol Med Res. 2015; 6(4): 5249-5253  |  PDF File


Transfusion transmitted infection is the major challenge in many parts of the world. To prevent those diseases screening of bloodwith improved technologies is necessary before transfusion. The aim of this study was to determine the prevalence and Sero-Positivity of blood borne infections like HIV 1& 2, HBV, HCV, Syphilis and Malaria among the healthy blood donors both voluntary as well as replacement donors. Methods: This was a retrospective study where record of pre- and post-donation tests done in blood bank of MNR Medical College& Hospital, India, between Januarys 2011 to December 2014. All processes and inputs were evaluated for predonation testing by simple rapid techniques and post donation screening by ELISA. Results: A total of 3,749 donors were screened of which 77 (2.05%) donors had seroprevalence for TTI’s. Individual seroprevalence rates of HIV, HBV, HCV and Syphilis were 0.18%, 1.60%, 0.16% and 0.10% respectively and interestingly we found that no donor affected with Malaria parasite. The seroprevalence rate for HBV fluctuated greatly during the study period while the seroprevalence of HIV, HCV & Syphilis were relatively consistent.Conclusion: Allthough it was a retrospective study, we conclude that effective screening of the most common and dangerous TTIs can reduce the risk of transmission. Blood transfusion services should establish proper system to screen correctly all donated blood for specific TTIs and only non-reactive blood or blood components are used for transfusion or manufacturing purpose