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Reliability of tnf-α as a screening test for cerebral stroke

Authors:Shubair M K , Saeed N S , Lutfi M F
Int J Biol Med Res. 2016; 7(1): 5374-5376  |  PDF File


Background: In spite of the pivotal role of TNF-α in the pathogenesis and clinical outcomes ofcerebral ischemia, this cytokine was never investigated before as an indicator of stroke. Aim Toinvestigate the reliability of TNF-αas screening test for ischemic stroke .Material and methodsThe study enrolled 35 patients with stroke and 81 apparently healthy volunteers. Followingclinical examination, blood samples were collected from each volunteer used for estimation ofTNF-α, random blood glucose (RBG), and lipid profile. TNF-α level ≥0.135 pg/ml was consideras significantly high concentration. Chi-square test and conditional ratios were used to assessassociation between higher levels of TNF-α and stroke. Results: Higher TNF-α levels wasassociated with higher risk of stroke (Odds Ratio (OR) = 6.37, 95% confidence interval (CI) =2.671 - 15.2), Sensitivity = 62.86%, Specificity = 79.01%, positive predictive value (PPV) =56.41%, negative predictive value (NPP) = 83.12 %, false positive rate (FPR) = 20.99%, falsenegative rate (FNR) = 37.14% and accuracy = 74.14%.Conclusion: TNF-α achieved significantlyhigher levels in patients suffering from recent stroke compared to apparently healthy subject.However, our results fail to demonstrate TNF-αas a reliable screening test for recent stroke.