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Liver function biomakers in malaria and hepatitis b co-infection among patients with febrile illness in kano metropolis

Authors:Sharif AA, Dabo NT, Getso MI, Yusuf I, Muhd IZ, Ahmad IM
Int J Biol Med Res. 2016; 7(1): 5377-5380  |  PDF File


Malaria and Hepatitis B Virus (HBV) infections are co-endemic throughout much of the tropical and Sub-Saharan Africa and both present major threat to public health. A study on the status of liver enzymes and serum protein in HBV and malaria co-infection was carried out on 200 patients presenting with fever to the General Outpatient Department (GOPD) of the Murtala Muhammed Specialist Hospital (MMSH) Kano using Gold Standard microscopy and rapid diagnostic test (RDT). The effect of mono and co-infection on serum protein and liver enzymes was investigated. Fifty one (25.5%) out of the total subjects studied were malaria positive. Females had higher rate of malaria infection with 18% prevalence than males with 7.5%. Age group 15-24 had the highest malaria prevalence (11%) followed by age group 25-34 with 6.5%. Thirteen (6.5%) subjects were HBV positive. Males had higher rate of infection with 4.5% prevalence than females with 2.0%. Nine individuals representing 4.5% of the total population had co-infection with higher prevalence observed among the males with 3.0%. Age groups 25- 34 were observed to have high co-infection rate of 1.5% and the least prevalence was observed among the age group 15-24 with 0.5% prevalence for both males and females. Biochemical analysis carried out on all the categories of subjects shows significant difference in mean values of AST and ALT in HBV group compared to other test groups P<0.05. However no significant difference was observed in the value of ALP in all the groups. Statistical difference was also established in ALB values between the co-infection and malaria groups (P=0.037) and between malaria and control group (P=0.022). There is also a statistical difference in the mean value of total bilirubin among the groups P<0.05 and mean value of DB between HBV and control groups (P=0.022). These findings ware discussed in the light of biochemical profiles in Malaria, HBV infection and co-infection with the two ailments.