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Impact of correction of anemia on major complication of chronic renal diseases

Authors:Atanu RoyChaudhry, Kapildev Mondal, Arijit Sinha, Balaram Tudu
Int J Biol Med Res. 2016; 7(2): 5540-5543  |  PDF File  |  Category: General Articles


Objective: To assess the impact of correction of anemia on the major complication of Chronic renal disease (CRD).Methodology: A prospective study evaluating the correction of anemia in CRD patients with recombinant human erythropoietin (rHuEPO) over a period of one year.Ejection fraction (EF), left ventricular mass index (LVMI), mini-mental status examination (MMS), cognition, focal neurodeficit and general sense of wellbeing (GSW) were measured by echocardiography, and appropriate scales on admission respectively at 3 months and 6months follow-up to find out the hemodynamic changes that could be achieved by correction of anemia. Results:Statistically strong significant (P<0.001) improvement of hemoglobin level occurred with rHuEPO therapy in the overall population, both at 3 month and 6 month follow-up. Statistically significant (P<0.05) improvement of EF occurred at 6 months follow-up in total population. At 6 months follow-up, there was significant change (P=0.015) of LVMI in total population. Even at 6 months follow-up, there was no significant change in the MMS (P=0.66) and cognition (P=0.20) of the study population, but significant improvement (P<0.001) of GSW occurred among the study population. There was also positive correlation between improvement of anemia with improvement of EF at 3 months follow-up (r =0.531). Conclusion: Correction of anaemia, even if partial, causes significant improvement in cardiovascular function as evidenced by increase in EF, even at short term follow-up of 6 months in our study. Anaemia of CRD also have an impact on neurological and GSW.