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Study of serum lipid profile and vitamin e in rheumatoid arthritis

Authors:Asitava Roy , Abhishek Dubey , Davina Hijam ,Ng. Arunkumar , O. Prabita ,Subhojit Das*, H. Lakhipyari Devi , Santa Naorem , e Th. Ibetombi Devi
Int J Biol Med Res. 2016; 7(2): 5544-5546  |  PDF File


Introduction: Rheumatoid Arthritis (RA) is a chronic systemic inflammatory disorder that may affect many tissues and organs but principally affects the joints.Aims and objects: To access serum lipid profile as well as atherogenic index – Total cholesterol/HDL cholesterol, LDL cholesterol/HDL cholesterol among the RA patients and compare the results with that of control group and also to estimate Vitamin E levels in cases and compare it with controls. Method: This study was conducted in Department of Biochemistry in collaboration with Department of Medicine in Regional Institute of Medical Sciences, Imphal. Fifty diagnosed cases of Rheumatoid Arthritis and thirty healthy age and sex matched individuals were included in this study. Serum triglycerides, HDL cholesterol, LDL cholesterol, VLDL cholesterol and Vit E were estimated in these groups. Results: Among cases the values of Vit E were significantly lower (0.25 ± 0.06 mg/dl ± SD) as compared to controls (1.12 ± 0.23 mg/dl ± SD). S. VLDL (30.09 ± 3.33 mg/dl ± SD) and S. LDL (220.96 ± 34.19 mg/dl ± SD) values were significantly higher among cases (18.57 ± 4.63 mg/dl ± SD, 36.2 ± 15.59 mg/dl ± SD respectively in controls).The value of S. HDL was found to be significantly lower (25.04 ± 6.27 mg/dl ± SD) in cases as compared to controls (58.83 ± 11.43 mg/dl ± SD). Among cases values of Total chol/HDL chol (11.78 ± 3.47) and LDL chol/HDL chol (9.48 ± 3.18) were also higher than controls (1.99 ± 0.42,0.66 ± 0.37 respectively)Conclusion: These findings strongly confirmed that patients with RA have significantly lower values of vitamin E and HDL compared to controls while higher values of other parameters of lipid profile and higher atherogenic indices