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Biochemical non-invasive prediction of hepatic fibrosis in patients with chronic hepatitis c genotype 4

Authors:Amr Amin* , Mohammed Mukhtar , Essam NoorEldin , Fahd Gethami , Fayez Hafez , Sameer Fatani , Neda Bogari , Abdullatif Babakr , Soud Khogeer , Ahmed Fawzy
Int J Biol Med Res. 2016; 7(3): 5647-5654  |  PDF File


Objectives:, Hepatic fibrosis detection is considered as a major independent predictor of treatment response in patients with chronic hepatitis C. Liver biopsy, represents the "gold standard" for evaluating liver fibrosis, however this method has prone sampling errors and completions. Currently used noninvasive predictors of fibrosis are considered less accurate than liver biopsy. We are aiming to reduce the use of the liver biopsy and instead evaluate the performance value of serum hyaluronic acid (HA), Collagen type IV (Coll-IV), and AST to platelet ratio index (APRI) as non-invasive diagnostic and stratification markers for hepatic fibrosis. Design and methods:, 104 Saudi patients with chronic hepatitis C genotype 4 were recruited for this study. Liver histopathological staging (F) was determined and serum hyaluronic acid and Collagen-IV were measured using ELISA techniques where, APRI was calculated. Results:, Both Collagen-IV and APRI significantly distinguished fibrotic patients from non-fibrotic group. The HA, APRI, and Coll-IV results discriminate early F0/F1 from F2/F3 (p<0.001). A combination of direct and indirect tests (Coll-IV and APRI) improved the performance with sensitivity and specificity. Conclusions:, The combination of APRI and Collagen-IV has a high diagnostic value in predicting moderate and severe fibrotic stages and could be clinically used as a diagnostic submitted for liver biopsy.