An evaluation of stress oxidative and serum electrolytes in female hypothyroid patients

Abstract

The thyroid hormones play an important role in many physiological processes. Variations in the levels of thyroid hormones can be one of the main physiological modulators of in vivo cellular oxidative stress. The present study evaluates the effects of hypothyroidism states on stress oxidative in female patients before treatment. 24 cases of overt hypothyroidism were chosen, 24 age matched controls were chosen. Blood samples were collected from them and T3, T4 and TSH levels were measured. Also, MDA, GSH, Sodium, Potassium and Chloride levels in blood was measured. Lipid peroxidation, an index of oxidative stress was significantly elevated (p <0.01) in hypothyroidism patients as compared to control. The results showed a highly significant decrease (p <0.01) in the levels of GSH in all patients with thyroid dysfunction as compared to control. The levels of serum sodium was significantly increased (p <0.001)in cases than controls.Mean serum potassium and chloride levels non-significantly changed in hypothyroid patients when compared to the control subjects. In hypothyroidismpatients, there was a significant negative correlation (r = 0.962; P < 0.05) between the levels of reduced glutathione with concomitant increase in MDA levels. No changes in TSHwere observed. There was a no significant correlation between serum MDA values and serum electrolytes levels.The results of this study reveal the importance of monitoring the levels of thosestress oxidative parameters and serum electrolytes levels in thyroid dysfunction patients before therapy, especially when the disease ismore severe.