Comparative study of lipid profile in hypothyroidism, hypothyroid patients taking treatment for more than 5 years and control group

Abstract

Objective: Hypothyroidism the most common functional disorder of the thyroid gland characterised by a cluster of clinical manifestations resulting from deficiency of thyroid hormones. 01% to 10% of the global population has some evidence of abnormally low thyroid hormones. Present study was undertaken to compare lipid profile in newly diagnosed hypothyroid subjects and hypothyroid subjects who were already receiving treatment for more than 5 years and to find out if there was any improvement in these parameters with thyroxine supplementation therapy. STUDY DESIGN: Cross-sectional case-control study. STUDY SAMPLE: 90 adults (Males & Females) of age group more than 30 years, divided into three equal groups of 30 subjects (28 female and 2 males) each belonging to the same socioeconomic status. Exclusion criteria: Individual with diabetes, hypertension cardiovascular, pulmonary, renal or liver diseases, pregnancy, other endocrine and dyslipidaemic disorders. Statistics applied: Statistically significant variation in three Groups determined by one way ANNOVA test and multiple comparisons between Group I vs. Group II, Group I vs. Group III, and Group II vs. Group III done by Tukey test. Results: It was found that mean value of serum Total cholesterol, Triglycerides, LDL-C, VLDL-C was significantly increased in Group II as compared to Group I and the mean value of serum HDL-C was decreased in Group II as compared to Group I. There were no significant difference found in serum Total cholesterol, Triglycerides, HDL-C, LDC-C and VLDL-C in Group I and group III. Serum Total cholesterol, Triglycerides, LDL-C, VLDL-C were significantly low in Group III as in comparison with Group II and the mean value of HDL-C was significantly high in Group III as compared with Group II. Conclusions: Thyroid hormones have significant effect on synthesis, mobilization and metabolism of lipids. Substitution therapy with levo-thyroxine significantly improves lipid metabolism abnormalities.