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Toxic effects of chronic inhalation of firewood smoke: a biochemical study in some food vendors in ajegunle

Authors:E.T. EGORO, M.M.WANKASI1 J.B.OKUTU
Int J Biol Med Res. 2017; 8(4): 6132-6134  |  PDF File

Abstract

The aim of this study was to assess the alterations of some plasma biochemical parameters induced by chronic inhalation of firewood smoke. Blood specimens were collected into heparinized anticoagulated bottles from 100 apparently healthy subjects with 50 of them by virtue of their occupation been exposed to firewood smoke for a period of 5-6 years (experimental group) while the remaining 50 have no evidence of exposure to firewood smoke (control group). The following biochemical parameters with specified methods were measured quantitatively: C-reactive protein (latex turbidimetry), alanine aminotransferase (colorimetric), aspartate aminotransferase (colorimetric), uric acid (enzymatic colorimetric), urea (urease berthlot), creatinine (Jaffe reaction) and cholesterol (enzymatic endpoint). The results showed statistically significant difference (p≤0.05) of plasma C-reactive protein, alanine aminotransferase and aspartate aminotransferase with mean values of 20.50mg/L, 27.40 U/l and 22.24 U/l respectively in the experimental group as compared with 0.16mg/L, 7.20 U/l and 7.0 U/l in the control group. The mean values of plasma uric acid, urea, creatinine and cholesterol were not significantly different (p≥0.05) in the experimental group as compared with that of the control group. The percentage of subjects in the experimental group having plasma C- reactive protein, alanine aminotransferase and aspartate aminotransferase concentrations above the existing reference ranges maximum of 6mg/L, 12U/l and 12U/l were 56%, 70% and 60% respectively. There was no elevation in the plasma concentrations of uric acid, urea, creatinine and cholesterol above the existing reference ranges maximum of 416mmol, 9.1mmol/l, 97µmol/l and 5.17mmol/l respectively as shown in the experimental group. In conclusion, this study has revealed that plasma C-reactive protein, alanine aminotransferase and aspartate aminotransferase are altered by chronic inhalation of firewood smoke for a period of 5-6 years. The routine estimation of these biochemical parameters in subjects exposed to firewood smoke for this period is thus recommended.