Abstract Objective:.To compare the effects of Maitland’s mobilization & McKenzie therapy on all parameters in patients with acute non-specific low back pain(NSLBP).Methodology: It was an experimental study. After screening 139 patients visiting the outpatient department, sample of convenience of 60 participants (35 males and 25females) between the age group of 18-45 years diagnosed as non-specific low back pain was included. Patients were divided into 3groups by simple randomization. Group A(conventional therapy and Maitland mobilisation) GroupB(conventional and McKenzie therapy).) GroupC (conventional therapy) Results: Group B had significant (p <0.05) alleviation in pain as compared to Group A & Group C. There was highly significant (p<0.01) improvement in lumbar flexion & extension in pre & post treatment measurements in Group A & Group B. But Group B showed highly significant (p<0.01) improvement as compared to Group A & Group C. While Group A & Group C showed very minimal reduction in disability score as compared to Group B.Conclusion: McKenzie therapy with an adjunct to conventional therapy resulted in greater alleviation of Pain, improvement in Lumbar ROM & also more reduction of Disability as compared to Maitland’s mobilization & only conventional treatment in patients with non-specific low back pain.