Anti-inflammatory activity of dimethyl cardamonin on formalin induced paw edema in albino rats

Abstract

Inflammation is a reaction of a living vascularised tissue to an injury. Conventional or synthetic drugs used in the treatment of inflammatory diseases are inadequate, it sometimes have serious side effects. Aim: The present study is aimed to evaluate the anti inflammatory activity of DMC on formalin induced paw edema in rats as for controlling inflammatory disorders. Methods: For anti inflammatory activity, albino rats were used and divided into 5 groups and treated accordingly: Normal control, Formalin induced group, Formalin+ DMC (100mg/kg bw), Normal+ DMC (100mg/kg bw) and Formalin+ Indomethacin (10mg/kg bw).After the experimental period of 7 days, the blood and tissue samples were collected and biochemical parameter and hematological studies were carried out. Result: Oral administration of formalin to the experimental animals produced reduction in the levels of SOD,GSH, GPX ,GR,GST,CAT, serum protein, total RBC and Hb. The animals treated with DMC extract at dose levels of 100mg /kg bw were significantly increased the levels of the above parameters. A significant increase in the length of the paw thickness, in the level of serum enzymes (SGOT, SGPT, ALP, CK) glucose and Lipid peroxide (LPO) was noted in the rats induced with formalin, while these levels were normalized by treatment with DMC conclusion: From the present observation, it is evidenced that Dimethyl cardamonin would be an effective drug for the treatment of inflammatory reactions.