Assessment of serum il6 levels in patients with diabetic nephropathy and its correlation with stage of chronic kidney disease

Abstract

Diabetic nephropathy is a state of inflammation where there is imbalance between proinflammatory and anti inflammatory cytokines. With uncontrolled elevation of proinflammatory cytokines , the inflammation would lead to renal fibrosis, of which few cytokines like IL-6,TNF@ were well studied (1-3) . Other inflammatory markers such as sialic acid and CRP-6 were also studied (4,5).IL-6 is a proinflammatory cytokine, thought to have major role in progression of various inflammatory diseases. It is well known that IL-6 levels are associated with progression of diabetic nephropathy. Chronic kidney disease being an inflammatory state is associated with high levels of serum IL-6.Though there are various biomarkers available to identify the progression of diabetic nephropathy, serum IL-6 as a biomarker for Diabetic nephropathy –CKD was not well studied. As both diabetes and CKD are inflammatory stages, it is understood that progressive elevation of serum IL-6 may be associated with progression of DN-CKD Hence we undertook this study to assess the serum levels of IL-6 in fifty sequential patients of different stages of CKD due to diabetic nephropathy. AIM : To assess the serum levels of IL-6 in patients of Chronic kidney disease due to diabetic nephropathy.