Inorganic fertilizers are used in association with organic manures to increase the natural productivity of ponds. However, indiscriminate use of inorganic fertilizers including ammonium sulphate, which releases ammonia has created numerous environmental hazards for fish populations The influence of ammonium sulphate on the oxidative stress performance of Indian major carp, Catla catla was investigated in a 30-days culture trial. Experimental ammonium sulphates were used in which ammonium sulphate at 148 mg/l. The oxidative stress performances was monitor at every 10 days of intervals and oxidative stress parameters measured at 10, 20 and 30 days intervals.