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Angiogenic modulatory activity of santol (sandoricum koetjape) ethanolic leaf extract observed through duck embryo chorioallantoic membrane (cam) assay

Authors:Albin Jay C. Tabamo, LPT, MSciEd-Bio
Int J Biol Med Res. 2021; 12(4): 7382-7385  |  PDF File

Abstract

aims This study aims to determine the angiogenic modulatory activity of Santol (Sandoricum koetjape) ethanolic leaf extract. It specifically attempts to investigate whether the S. koetjape ethanolic leaf extract exhibits an angiogenic inhibitory or exacerbatory effect to duck embryo chorioallantoic membrane. methods Tannin, a component of santol leaves believed to have anti-angiogenic property, was produced through ethanolic extraction. Extracts were divided into 20 milligram/millilitre, 30 milligram/millilitre, and 50 milligram/millilitre and were applied to the duck embryo chorioallantoic membrane. Pure ethanol solution was used as control. results Results of visual examination and quantification showed the ethanol-treated assay mean branching points of 508.7. Those treated with 20 milligram/millilitre, 30 milligram/millilitre, and 50 milligram/millilitre showed 485.7, 335.0, and 286.7, respectively. conclusion These indicated inverse proportional relationship of the concentration of S. koetjape ethanolic leaf extract and the number of branching points in the duck embryo chorioallantoic membrane concluding that santol can be a potential remedy to cancer.