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A study on resistance pattern of bacteria isolated from diabetic and non- diabetic ulcers

Authors:Joana Mary Magdaline, Akhila Aravind
Int J Biol Med Res. 2021; 12(4): 7386-7392  |  PDF File

Abstract

Background & Objectives: Epidemiological data from various studies shows that the prevalence of chronic ulcer is high in Indian population which has a significant impact on health care. Bacteriological profile & their antibiotic resistance pattern shows a region wise variation in different types of ulcers. The present study was conducted to compare the prevalence of diabetic and non- diabetic ulcers in patients admitted in surgical wards as well as to determine the resistance pattern of bacteria isolated from the ulcers. Methods: This descriptive study, which was conducted in the Departments of Microbiology & Surgery, included 103 patients admitted with ulcers in surgical wards. Samples from the ulcers were collected using sterile swabs. The isolates were identified using standard microbiological methods & sensitivity/resistance pattern determined by Kirby- Bauer disc diffusion method. Results & Discussion: In the present study 142 bacterial isolates were obtained from 103 patients. Most prevalent type of ulcers among the study population was diabetic ulcers (54%). On comparison of flora of the three major types of ulcers (diabetic, venous &decubitus) in our study, it was observed that all of them had a predominant monomicrobial infection with equal proportions of Gram positive & Gram-negative isolates. This was in discordance with other studies who reported a Gram-negative predominance. An overall Gram-negative predominance was observed but the most frequent isolate was Staphylococcus aureus. There is a higher prevalence (79.5%) of multi drug resistant (MDR) isolates in our study when compared to other studies. All Gram-positive isolates were resistant to Penicillin & Erythromycin. Gram negative bacteria showed 100% resistance to Ampicillin Conclusion: An increased prevalence of MDR bacteria in ulcers was observed in this study. Hence to promote healing, judicious use of antibiotics should be followed in patients with chronic ulcers.