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Prediction of 10 –year risk of cardiovascular disease in post-menopausal women in south india.

Authors: Anitha G, Sivakumar.J ,Kalavathy Ponniraivan
Int J Biol Med Res. 2021; 12(4): 7397-7401  |  PDF File


Background: Menopausal health in our social environment have received minimal awareness among women. Dyslipidaemia, which has been more prevalent among postmenopausal women have made them more susceptible to cardiovascular risks. Objective: To estimate serum lipid profile and atherogenic index of plasma in postmenopausal women compared with premenopausal women. Material and methods: This case control study involved 50 postmenopausal women (cases) aged between 50 -70 years and 50 pre-menopausal women (controls) aged between 30–40 years. Total cholesterol (TC), and their sub fractions: high density lipoprotein cholesterol (HDL-C), very low density lipoprotein cholesterol (VLDL- C), low density lipoprotein cholesterol (LDL-C) and triglycerides (TG) were analysed. Atherogenic index of plasma (AIP); log (TG/HDL –C) was calculated and compared between the cases and control group. These parameters were also compared with 5 yrs post menopausal and 10 yrs postmenopausal women, to assess the cardiovascular risks with increasing years. Results: There was statistically significant increase in TC, TG, LDL-C, VLDL-C and AIP with p value: <0.05 and decrease in HDL-C in postmenopausal women compared with premenopausal women. There was statistically significant derangement of lipid subfractions as the duration of menopause increased. Conclusion: Menopause, undoubtedly alters lipid profile. Atherogenic index of plasma being triglyceride based index definitely can add significant value in assessing atherosclerosis and cardiovascular risks in postmenopausal women.