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Evaluation of high sensitivity C-reactive protein and lipid profiles as predictive factors in women with preeclampsia

Authors:Modak R, Biswas DK, Singh R, Pal A
Int J Biol Med Res. 2022; 13(1): 7429-7433  |  PDF File

Abstract

Abstract: Objectives: To evaluate the serum hs-C- reactive protein and lipid profiles in women with preeclampsia as predictive factors. Methods: A prospective observational study was conducted in the department of obstetrics and gynecology, Burdwan Medical College, Burdwan over 126 antenatal mothers. Singleton pregnant mothers in the age groups of 18-35 years with the features of preeclampsia were selected as a case (n=62). Age matched normotensive pregnant women were included in the control groups (n=64). Demographic variables and haematological investigations including high sensitivity CRP, total cholesterol (TC), HDL- cholesterol, LDL-cholesterol, VLDL- cholesterol, triglycerides of all the pregnant women in our study were measured in the third trimester of pregnancy. Serum lipid profiles and hs-CRP were measured again at 48 hours after delivery in both case and control groups to find out any relevant changes. Results:The level of serum hs-CRP in preeclamptic women in third trimester (15.45±3.27 mg/L) as compared to normal pregnancy (4.06±1.54) was highly significant (p<0.001). The serum level of hs-CRP at 48 hours postpartum in preeclamptic mothers was also higher (38.07±3.89mg/L) than normotensive women (13.48±2.07 mg/L). In preeclamptic women, different lipid levels like serum total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and very low-density lipoprotein cholesterol (VLDL-C) were significantly high (p<0.001) at the time of enrolment. In preeclamptic disorders, the absolute changes of LDL and HDL cholesterol levels in the third trimester of antenatal period and 48 hours postpartum were 12.55±1.83 mg/dl and -5.21±0.79 mg/dl respectively where as these figures were 17.66±1.64 mg/dl and -7.64±0.68mg/dl respectively in normotensive women. Predictive accuracy in terms of AUROC in preeclamptic mothers were high in hs-CRP (1.00, 95%CI, 1-1), triglyceride (1.00, 95% CI,1-1), VLDL-C(1.00,95% CI,0.999-1) during enrolment in third trimester of pregnancy and hs-CRP (mg/L) in 48 hours postpartum (1.00,95% CI,1-1). Conclusion: High serum hs-CRP level as well as dyslipidaemia were associated with pathological process of preeclampsia and helps in prediction of preeclampsia.