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CLINICAL PROFILE AND TREATMENT OUTCOME OF GUILLIAN BARRE SYNDROME IN CHILDREN

Authors:S.Selvakumar, V.Boopathy, Senthil murugan.S , Kumaravel, Narayanan.E
Int J Biol Med Res. 2022; 13(1): 7438-7443  |  PDF File

Abstract

INTRODUCTION: Guillain Barre Syndrome (GBS) is a post inflammatory polyneuropathy characterised by relatively symmetrical limb weakness, areflexia, variable autonomic disturbance and absent or mild sensory signs. GBS remains the most common cause of acute flaccid paralysis. This study aims to find out the clinical profile and treatment outcome of Guillian Barre syndrome in children. AIMS &OBJECTIVES: To study the demographic variables, clinical manifestations and electrophysiological features in children with various subtypes of GBS and assess their outcome on follow up. METHODOLOGY: Prospective cohort study done in Institute of Child Health & Hospital for Children, Madras Medical College, Chennai, Tamilnadu. Study period was from November 2011 to October 2013.Children <13 years diagnosed as Guillain Barre Syndrome based on Asbury's diagnostic criteria were included. Demographic characteristics, clinical manifestations, nerve conduction studies, recovery was assessed. Stastistical analysis was analysed by Fisher's test .RESULTS: 90.6 %( 39 children) of patients had preceding illness. Bulbar involvement was most common cranial nerve involvement. Autonomic dysfunction was noted in 12children (28%) of which 11 children required assisted ventilation and 2 children died. 60 % of children had combination of lower limb ,upper limb and trunk involvement . Albumin- cytological dissociation was noted in 23children(53.5%).Nerve conduction studies revealed AIDP as most common variant CONCLUSION : Early identification of cranial nerve involvement and autonomic dysfunction plays an pivotal role in reducing morbidity and mortality in GBS children.